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In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates

doi: 10.1016/j.placenta.2018.04.012 36 TuuliMGLongtineMSNelsonDM

Now, there are a bunch of theories as to why the pineal regresses with age

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