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GSE displays promising antibacterial and antifungal properties

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Compounds spanning 100-fold IC50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

Additionally, it increased the contents of cardiac thioredoxin (Trx) and GSH, decreases oxidative stress micro-RNA (miR)-200a and Nrf2