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Pu B, Lu Y, Chen J, Li S, Zhu N, Wei W, et al

Ferroptosis-inducing compounds exert their effect primarily through the direct inhibition of GPX4, a key antioxidant enzyme responsible for reducing lipid hydroperoxides to non-toxic lipid alcohols

Several metal-based nanoparticles harboring multivalent elements, such as Cu 2+ /Cu + , Mn 4+/3+ /Mn 2+ , Mo 6+ /Mo 4+ , and Ir 4+ /Ir 3+ , possess strong oxidization, and can directly react with GSH (Nie et al., 2022)

Among them, PUFAs can penetrate the sperm cell membrane, improve the scalability of the sperm plasma membrane, maintain its structural and functional integrity, enhance the osmotic resistance of the acrosome membrane, and provide protection against physiological or thermal changes during cryopreservation (12, 13)

By activating mTOR, BCAAs enhance the motility of the trophectoderm, a critical step for blastocyst activation and successful embryo implantation 304,316,317,318,319 (Fig