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*Correspondence: Xuezhong Gong, [email protected] This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Because of the longer half-life time compared to the alkoxyl radical, peroxyl radical is ideal for propagation of oxidative chain reactions, while the oxidation of alkoxyl radicals produce dihydroperoxide, which is degraded to toxic aldehydes, such as 4-hydroxy-2,3-trans-nonenal, 4-hydroxy-pentanal, short chain malondialdehyde