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10.1146/annurev-phyto-082712-102340 126 Pislewska-BednarekM.NakanoR

Canagliflozin dose-dependently improved renal function, enhanced the antioxidant capacity of aortic tissues and reduced calcium deposition in rat aortas and kidneys

Effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole on DNA synthesis of cultured human fibroblasts

These are some examples of how OoC technology can represent a next-generation preclinical testing tool, moving beyond conventional toxicology toward precision immuno-oncology, where patient-derived chips could guide therapeutic decisions and dose optimization while reducing reliance on animal models

Acid erosion happens much faster when the mucosal barrier is compromised, and that upper GI damage often leads to inflammatory diarrhea further down the tract