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Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)

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628,629 The resultant mRNA is translated in the cytosol, 628,629 after which the mitochondrial targeting peptides facilitate the import of these proteins into mitochondria, achieving the allotopic expression of functional mtDNA genes to compensate for genetic defects