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doi: 10.1097/00007890-200203270-00011 167 RavaioliMBaldassareMVasuriFPasquinelliGLaggettaMValenteSet al

Notably, low COMT methylation has also been detected in saliva samples from schizophrenia and bipolar disorder patients, suggesting potential cross-tissue relevance and supporting the development of non-invasive biomarkers (Abdolmaleky et al., 2006)