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Recent meta-analyses highlight significant heterogeneity in study designs, dosing protocols, and outcome measures, making it difficult to draw definitive conclusions about EGCGs therapeutic efficacy

[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Vetvicka V, Vetvickova J

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However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)