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Patients with significant gastroparesis, history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, or pancreatitis warrant particular care with the GLP-1 component, regardless of the AOD-9604 question

Often studied for its interaction with mechanisms associated with fat metabolism

Structure-Activity Relationships and Medicinal Chemistry The optimization of orforglipron from the initial hit compound to a clinical candidate exemplifies modern medicinal chemistry approaches applied to a novel target class