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The Web of Science search strategy was: AB=(children OR pediatric) AND AB=(growth hormone OR growth hormone deficiency OR growth hormone treatment OR recombinant growth hormone) AND AB=(sleep quality OR sleep pattern OR sleep duration OR sleep efficiency OR sleep satisfaction OR sleep health) AND AB=(sleep study OR questionnaires OR polysomnography) NOT AB=(syndrome) NOT AB=(review OR case report)

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Finally, we review current preclinical efforts to target FSP1, with emphasis on small-molecule inhibitors, mechanism-based combinations, candidate biomarkers, and major translational challenges

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Under physiological conditions, autophagy plays a protective role in maintaining cellular homeostasis and may induce cell death only when it is excessively activated or when the autophagic flux is blocked