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Rapid Identification and Pharmacokinetic Studies of Multiple Active Alkaloids in Rat Plasma through UPLC-Q-TOF-MS and UPLC-MS/MS after the Oral Administration of Zanthoxylum Nitidum Extract

The data were fitted to a nonlinear substrate inhibition model ( y = V max x /( K m + x (1 + x / K i ))

NNMT influences this regulatory landscape via: Reducing SAM availability for DNA and histone methylation Causing altered chromatin states that can activate oncogenes or silence tumor suppressors Facilitating oncogenic reprogramming in both tumor cells and stromal microenvironment 9

Glutathione is involved in the detoxification of both xenobiotic and endogenous compounds