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These comparator categories were prespecified to keep comparisons clinically meaningful and to avoid pooling different control types that could blur ALCs added effect

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Patients were randomized to follow a therapeutic cycle for a total period of eight years: citicoline (1,000 mg/day, by intramuscular injection) or placebo (-blockers alone) for a two-month period followed by a four-month washout period (87)

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j, the time point of every study