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pylori infection increases phosphohistone H2AX, a marker of repair for double-strand DNA breaks (46)

Eur Endocrinol 12(2):9698 Nez A, Bedregal P, Becerra C et al (2017) Alteraciones del neurodesarrollo en pacientes con hipotiroidismo congnito: recomendaciones para el seguimiento [Neurodevelopmental assessment of patients with congenital hypothyroidism]

Knockout of Krppel-like factor 14 (KLF14) and Krppel-like factor 15 (KLF15) in renal tubular cells, as well as activation of activating transcription factor 6 (ATF6) overexpression, can inhibit PPAR, reduce FAO mitochondrial activity, lead to lipid accumulation and insufficient energy supply in renal tubular cells, increase apoptosis, and ultimately cause lipotoxicity-induced RF [45,46,47]