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Exploration of uncharted regions of the protein universe

None of the other chromosomes bears all the three genes

Moreover, elevated levels of leptin, a prevalent occurrence in individuals with obesity, have been shown to stimulate the secretion of vascular endothelial growth factor (VEGF) by airway ASM cells (293), suggesting that leptin may indirectly contribute to the obesity-induced bronchial vascular remodeling processes in individuals with asthma and obesity

Diabetes affects the activity of many metabolic pathways (AGEs, PKC, polyol pathway, PP), and one consequence of activating these metabolic pathways is the generation of ROS (Kowluru, 2023)