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Although both have benefits, the right option often depends on patient preferences, symptoms, and absorption rates

One Cochrane review found that high-dose oral vitamin B12 supplements (1,000 mcg to 2,000 mcg per day) was as effective for correcting megaloblastic anemia as B12 shots

Many people notice an improvement in energy levels within a few days to a few weeks, depending on how low their vitamin B12 levels were

Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency

Inhibiting NNMT increases cellular NAD+ levels, which activates sirtuin pathways and promotes fatty acid oxidation