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Functionally, ferroptosis serves as an essential physiological mechanism for the maintenance of homeostasis in the bodys internal environment, as well as a pathological mechanism underlying the onset and development of human diseases

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Interestingly, the redox state of Glutathione in the IMS is mainly regulated by the cytosolic Glutathione reductase system, which directly impinges on the activity of IMS enzymes such as Mia40