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In clinical trials, Cucurbita Maxima improves skin tone, reduces dark spots and other signs of aging, as well as prevents wrinkles

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One unit (1 U) of activity is defined as the amount of enzyme releasing 1 mol of product per minute under the defined reaction conditions [17]

The following sections detail these mechanisms, highlighting both shared pathways and tissue-specific actions in skin and mucosal ( FIGURE 2 3.1 Activation of protective systems: The Nrf2 antioxidant pathway Oxidative stress is a common driver and amplifier of inflammation ( 3.1.1 Photoprotection and antioxidant defense in skin Ultraviolet (UV) radiation is a primary oxidative stressor for skin ( 3.1.2 Mitigating oxidative stress in mucosal tissues Mucosal tissues are frequently exposed to oxidative challenges from various sources, including pathogens, chemicals, and drugs, which can lead to tissue damage and inflammation ( In the digestive tract, in the context of Helicobacter pylori infection, sea buckthorn organic acid extracts (SOA) was shown to reduce ROS and pro-inflammatory cytokines, such as interleukin (IL)-, IL-6, and IL-8, in gastric mucosal cells, indicating its direct role in countering oxidative and inflammatory pathways ( Hippophae rhamnoides ssp