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However, despite the progress that has been made with the 3D cocultures, preclinical (animal) models, especially the application of mice remain the common experimental system that is currently used to study the pathogenesis of DILI [5254]

Discussion The ReCePI study aims to demonstrate the safety and efficacy of amustaline/GSH pathogen-reduced RBCs in subjects treated for acute anemia related to bleeding where transfusions are indicated to prevent tissue hypoxia