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The binding of the SARS-CoV-2 spike glycoprotein with ACE2, which triggers the virus-mediated cellular uptake, can also cause a burst of inflammatory cytokine release (a cytokine storm) partially because of the decreased availability of functional ACE2

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ACS: acute coronary syndrome

In patients with ME/CFS, research has shown that the Krebs cycle is often impaired, with blockages occurring at specific enzymatic steps