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As indicated above, vitamins E and C and their respective derivatives have largely failed to provide therapeutic benefits in many studies because of some possible reasons

10.1016/j.phymed.2016.11.016 [DOI] [PubMed] [Google Scholar] Tan C., Chng Y., Loh Y., Zaini Asmawi M., Ahmad M., Yam M

However, sustained high doses, overdose, fasting, alcohol use, or pre-existing liver disease can overwhelm glutathione reserves, increasing risk of hepatotoxicity and oxidative stress