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A typical alternative treatment to induce ovulation in clomiphene citrate-resistant PCOS patients is gonadotropin therapy

Additionally, studies report that MT2 binds also MC-4R receptors and has been observed to influence glucose and cholesterol metabolism and sexual behavior, and to induce thermogenic and anorexic responses

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However, PTZ electron micrographs demonstrated a shrunken nuclear membrane and increased heterochromatin, with marked loss of the rough endoplasmic reticulum and disrupted mitochondria (C-shaped) in the cytoplasm