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Centrally, the brain hypothalamus and brainstem regions are well-known sites for glucose sensing and uptake, primarily through the glucose-excited (GE) and glucose-inhibited neurons ( Although the contribution of GPCRs to glucose homeostasis is widely recognized, the precise role of adipocyte GPCR signaling in direct glucose sensing is incompletely understood

Although surgical intervention is the main therapeutic strategy of choice, molecular targets need to be identified for prevention, early detection, and pharmacotherapeutics

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