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Restoring normal neurological function, or at least slowing disease progression, should be the focus of new therapies to address DN

In 2020, a related study (28) demonstrated that overexpression of miR-140-3p inhibited the proliferation of human cervical cancer cells by targeting down-regulation of RRM2 inducing cell cycle arrest and early apoptosis, while decreasing BCL-2 protein levels and inducing a significant increase in BAX and caspase-3 protein levels

nevertheless, supplementation of NSO and NSS mitigated this adverse effect to varying degrees through their antioxidant, anti-inflammatory, and anti-apoptotic properties, which underlie their protective performance against hepatorenal damage in response to AZA administration

PMCID: PMC5588976