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Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3 signaling pathway

A full validation of the methods was performed according to the current guidelines

However, the current research remains largely limited to animal models and small-scale clinical trials, necessitating further large-scale, multicenter clinical studies to validate their efficacy and safety

This effect is a consequence of the increase in 2,3-bisphosphoglycerate concentration in red blood cells