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However, naltrexone, as an opioid antagonist, may increase GABAergic interneuron activity, thereby enhancing GABAergic tone, which could lead to reduced glutamate release from pyramidal neurons and a consequent attenuation of ketamines acute excitatory effects

Diabetes Care Ferrannini, E

doi: 10.1085/jgp.200609533

doi: 10.3390/molecules17021571 35 LiuXZhangJDiYWanHWangKNieJ

Acknowledgments The authors would like to express their sincere gratitude to Ilya Raskin for granting permission to reproduce Figure 2 in this article