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GPX family is present in all cells, primarily located in the cytosolic and mitochondrial compartments, as well as the peroxisomal compartment [30] in some cells

The best-studied and characterized genetic variant in MBOAT7 is the polymorphism rs641738, which leads to a substitution of cytosine (C) with thymine (T) at position 641738 in the gene

Surgeries that affect the stomach where intrinsic factor is made, or the ileum (the last portion of the small intestine) where vitamin B12 is absorbed, can increase the risk of a deficiency