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Growth media for CHO cells was prepared with 94% Hams F-12, 5% fetal bovine serum (FBS) and 1% antibiotics

Abraham 2005)

Description Amount per serving: Serving size: 5 ml (1 tsp.) Servings per container: 20 Ingredients: Thiamin (Vitamin B1) as thiamin hydrochloride 12,5 mg Riboflavin (Vitamin B2) (as Riboflavin 5-Phosphate) 7,5 mg Niacin (Vitamin B3) (as Niacin, Niacinamide) 10 mg Vitamin B6 (as Pyridoxine hydrochloride) 7,5 mg Folate (as Calcium folinate) 500 g Vitamin B12 (as Methylcobalamin) 500 g Biotin 500 g Pantothenic acid (as d-Calcium pantothenate) 25 mg Sodium 20 mg Opitac Glutathione 325 mg Betain Anhydrous (Trimethylglycine) 25 mg Milk Thistle Extract 57,5 mg Phospholipids (from purified sunflower seed lecithin) 400 mg Other Ingredients: Water, Glycerin, Ethanol, Vitamin E (as Tocofersolan and Natural Mixed Tocopherols), EDTA (as preservative) Natural Plant Flavoring (no MSG), Natural Citrus and Mint Oils

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SHMT2 also exerts influence on tumor cells ability to migrate and proliferate, supporting metabolic adaptations through Akt2 and n-Myc activation in human neuroblastoma cells [121], or hypoxia inducible factor 1 (HIF-1) activation in human gastric cancer cells [122]