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doi: 10.1126/science.1241165 90 SpaggiariG.BriganteG.De VincentisS.CattiniU.RoliL.De SantisM

5 Discussion and perspectives In recent years, in OA, a complex degenerative joint disease, increasing research indicates that ferroptosis not only exists in the pathological process but is also closely related to pathological features such as articular cartilage degeneration, synovial inflammation, and subchondral bone changes

Chronic injuries especially may require 8 to 12 weeks before significant improvement becomes apparent

These results may not generalise to other microbes or eukaryotic cells

CCR9 + Tfh cells specifically express Bcl-6, ICOS and other inflammatory mediators, including IL-7, IL-21, and IFN- (86)