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This unified mechanism offers a coordinated therapeutic strategy for sepsis-induced organ injury

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GSDMD-NT has a high affinity for phosphatidylinositol phosphates and phosphatidylserine, which are primarily located on the inner surface of the plasma membrane, thereby minimizing damage to adjacent cellular membranes [182]

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There is, however, one last piece of the puzzle left to reveal

This study revealed extensive neuronal degeneration and necrosis, along with pronounced hyperemia in meningeal and parenchymal tissue, in the DM group