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demonstrated that elevated TIPE2 expression in NK cells correlates with NK cell exhaustion, contributing to poor prognoses in both human and mouse cancer models

This reinforces the role of DAP as an early trigger for vasopressor initiation, rather than waiting for MAP to fall

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Reactive astrocytes during ageing also show increased expression of genes related to complement system activation such as C3 and C4b, as well as expression of genes related to antigen presentation such as MHC-II and markers of inflammation such as NFB (Lee et al., 2000