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The isoelectric point of a solution is reached when the positive and negative charges of amphoteric ions are equal

Key findings from cartilage research [7] : In vivo experiments used collagenase-induced osteoarthritis rabbit models Intra-articular AOD9604 injections enhanced cartilage regeneration Morphological assessments showed significantly improved cartilage structure Reduced degeneration scores compared to control groups Combined treatment with hyaluronic acid produced additive positive effects superior to either agent alone Chondrocyte Stimulation Studies Research suggests AOD9604 may promote differentiation of myoblasts and stimulate chondrocytes to produce extracellular matrix components [7]

The samples were diluted by 100 times and measured using LCMS in the selective ion mode

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Chirurgia (Bucur) 112:110116 Severance T, Rahim M, French J, Baker R, Shriner A, Khaitan A, Overholt K (2020) COVID-19 and hereditary spherocytosis: a recipe for hemolysis