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Disclosures: Tarik Asselah: Nothing to Disclose, Anca Streinu-Cercel: Nothing to Disclose, Alina Jucov: Nothing to Disclose, Edward Gane: Nothing to Disclose, Heiner Wedemeyer: Nothing to Disclose, Pietro Lampertico: ROCHE PHARMA/DIAGNOSTICS, GILEAD SCIENCES, GSK, ABBVIE, JANS: Advisor, Michael Chattergoon: Nothing to Disclose, Sophia Chow: Nothing to Disclose, Pan Wu: Nothing to Disclose, Cara Pilowa: Nothing to Disclose, Todd Correll: Nothing to Disclose, Carey Hwang: Vir Biotechnology, Inc: Employee and stock holder, Kosh Agarwal: Nothing to Disclose 2626 CANCER-INDUCED REPROGRAMMING OF MACROPHAGE NUCLEOTIDE METABOLISM DISMANTLES ANTI-TUMOR IMMUNITY Shuang Liang 1 Chuanli Zhou 2 Zhenyu Zhong 1 , 1 University of Texas Southwestern Medical Center, 2 UT Southwestern Medical Center Background: By establishing a pro-inflammatory and pro-tumorigenic environment within the liver, tumor-associated macrophages (TAMs) play a crucial role in propelling the progression of hepatocellular carcinoma (HCC) the dominant form of primary liver cancer