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Second, the arginine at position 3 in the native sequence was substituted with leucine (hence R3)

PMID: 29851929

It works as a signaling molecule, telling your cells to do certain things

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Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib