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Further research has shown that TPC2 counterbalances OCA2, a positive regulator of pigmentation, by increasing the melanosomal membrane potential to decrease melanin content

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Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments

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2009;297(2):L388-400

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It did not include histopathological analysis of brain tissue, which could confirm structural changes related to neurochemical and oxidative shifts

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