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In the healthy brain, astrocytes contribute to tonic inhibition by synthesizing and releasing GABA through nonsynaptic mechanisms

However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs

One naturally occurring peptide, Epithalamin, produced in the pineal gland, has been linked to increased melatonin production, enhanced immune and anti-carcinogenic functions in rodent models, and restoration of reproductive function in aged rodents