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Some examples include spontaneous conversions, replication errors, exposure to free radicals, etc

Pi-class glutathione S-transferase: regulation and function

Lake, J

The features listed by Hanifin & Rajka (1980) are those referred to most often in the literature

Accumulation of oxidized biomolecules associated with degeneration of DA neurons indicates the involvement of oxidative stress mechanisms [1], and the highly oxidizable aromatic structure of DA and its metabolites are thought to contribute to these processes [2]