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Furthermore, NADPH is required for many anabolic pathways such as nitric oxide and fatty acid synthesis, however, NADPH consumption in the aldose reductase pathway under diabetic conditions causes a harmful effect on the biosynthesis process of these molecules in the retina (Thakur et al., 2021)

It interacts with the nitric oxide system through the VEGFR2-Akt-eNOS axis and the Src-caveolin-1-eNOS pathway [PMID: 40789979]

Biomolecules (2021) 11(11):1588

The authors also searched the ClinicalTrials.gov ( and the International Clinical Trials Registry Platform ( to ensure that the search was comprehensive and to minimize publication bias

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