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Most vials have a small circle or target indicating the thinnest, most easily punctured area

10.3390/ijms232213895 146

Death receptor-mediated exogenous pathways In the exogenous apoptotic pathways, cisplatin binds to death receptors such as tumor necrosis factor receptor 1 (TNFR1), TNFR2, and FAS on the cell membrane to activate caspase-8, which further activates caspase-3, ultimately leading to apoptosis [40]