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The intranasal forms of methylcobalamin, vitamin B12, should be administered at least 1 hour before or 1 hour after ingestion of hot food or liquids

10.1152/japplphysiol.01077.2006 137 SwaminathanS.BirudukotaS.ThakurM

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However, on average patients will see a response from the vitamin B12 injections around 48 to 72 hours after, with brisk production of new red blood cells