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These FRDA animal models are either mildly symptomatic due to insufficient reduction of frataxin (greater than 75%) or engineered to be tissue-specific conditional knockouts

J Sea Res 39:125137 Johnson LL, Collier TK, Stein JE (2002) An analysis in support of sediment quality thresholds for polycyclic aromatic hydrocarbons (PAHs) to protect estuarine fish