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A second significant response to chronic tobacco smoke exposure is the generation of reactive oxygen species (ROS), which overwhelm the cellular antioxidant defense system, primarily centered around glutathione (GSH) [11, 12]

TABLE 1 Advantages and disadvantages of 2D and 3D-cell cultures as model of neurodevelopmental and neurodegenerative diseases and mitochondrial disorders

60 LaplantineE.FontanE.ChiaravalliJ.LopezT.LakisicG.VeronM.et al (2009)