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Ion transporters, such as sodium pumps, calcium transporters, and potassium channels, are essential in regulating neuronal cell electrophysiological activity and maintaining CNS ion concentration gradients [24]

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Eur J Neurosci 32:17351743 Shippenberg TS, Bals-Kubik R, Herz A (1987) Motivational properties of opioids: evidence that an activation of delta-receptors mediates reinforcement processes

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Cryotherapy for small joints like hands and wrists works well with ice water immersion or specialized cold wraps