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Each Frizzled protein contains a N-terminal extracellular cysteine-rich domain (CRD), through which Wnt ligands bind to Frizzled receptors

Resistant mutations in CML and Ph+ALLrole of ponatinib

Therefore, the balance of Rac1/Cdc42 and RhoA activity may be critical for establishing and maintaining the homeostasis of dendritic spine density in the brain