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Increased deformability of erythrocytes may improve the rheological properties of blood and thus hemodynamics in humans, resulting in better tissue oxygenation

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Refractory cases may require splenectomy, intravenous gamma globulin, plasmapheresis, cytotoxic agents, or danazol (Danocrine)

Satir & Guzel-Seydim, 2015

It is worth noting that inhibiting CYP19A1 also upregulated PD-L1 expression [122]