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Auton Neurosci 160:8289

Nevertheless, given the demonstrated tolerability of CoQ10 and the numerous benefits it has been shown to provide in clinical trials of other conditions, supplementation may still be reasonable for some people with Parkinsons disease, or even those at a higher risk for developing the disease

Overactivity of the arginine-to-ornithine pathway may lead to arginine depletion, resulting in an imbalance between cartilage repair and degradation [10]

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However, certain conditions like pregnancy may result in increased excretion of L-carnitine, potentially increasing the risk for deficiency