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Next, we demonstrated that replicating key aspects of the lung alveolar micro-environment specifically, the airliquid interface (ALI), breathing-like motions (stretch), and the inclusion of an immune component significantly enhances the sensitivity of the smoke-induced lung-on-chip model

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doi: 10.1172/JCI18797 39

Strassburger, K

In parallel, immunosuppressive cells and cytokines within the TME can dampen the immune response, making it difficult to achieve the desired therapeutic outcome [142,143,144]