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Contrary to the anti-ferroptotic properties of membrane-bound CD91, the soluble form (sCD91) participates in microglia activation and induction of a pro-inflammatory state [105]

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[332] Filmography and awards Prolific in film since 1985, Reeves's most acclaimed and highest-grossing films, according to the review aggregate site Rotten Tomatoes, include: River's Edge (1987), Bill and Ted's Excellent Adventure (1989), My Own Private Idaho (1991), Much Ado About Nothing (1993), Speed (1994), The Matrix (1999), John Wick (2014), John Wick: Chapter 2 (2017), John Wick: Chapter 3 Parabellum (2019), and Toy Story 4 (2019)

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