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doi: 10.1016/j.biocel.2006.07.001 288 VerasF

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Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J

In a state of mitochondrial dysfunction, partially metabolized fatty acids can build up inside the mitochondria, forming toxic acyl-CoA compounds that inhibit essential enzymes and cause severe oxidative stress