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Haanen J, Ernstoff MS, Wang Y, Menzies AM, Puzanov I, Grivas P, et al

FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

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While this study was specifically conducted in women, men with insulin resistance are also likely to benefit

The causative role of increased intestinal permeability and microbiota imbalance has been the focus of research interest since gastrointestinal symptoms are very common in autism spectrum disorder