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Physiological roles of MG and the glyoxalase system The glutathione dependence as a co-factor for Glo-1, the non-enzymatic origin of MG from triosephosphates and the fact that the end-product is D- rather than L-lactate, isolate MG and Glo-(1 and 2) from glycolysis, leaving this system orphan in function

doi: 10.1080/21505594.2021.1871822 301 SprattB

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Crucially, melatonin lies at the intersection of many of these processes